The novel should not contain a harem, for some reason, I find it repulsive. The setting should take place in a futuristic scene (intersellar). It can be Yuri/BG/Bl. Though I prefer bl the most. The Mc should be op and calm in various situations, kinda like a Gary Stu or Mary Sue. It can be a CN novel.
Crossing to the Future, it’s Not Easy to Be a Man is the only thing that comes to mind. It's not exactly comedy and the (BG) romance is late and slow, though.
The way of the Empress, I read it yesterday and it meets your requirements, personally it is only so-so for me
Bursting After He Transmigrated into the Cannon Fodder Omega Born to Be Rebellious [Quick Transmigration] Quickly wear the Face Of the Devil
Mist -it’s an unlimited flow but with strong sci fi and futuristic elements. MC is super smart and strong
It's very very late. But if you read the first translations by Lingtian, you can see somnious' countdown to the ml appearing, and his relationship with MC remains platonic for hundreds of chapters after his introduction. Yes, there is definitely romance in it. Is it the major part of it? No, I would say it's a subplot.
Supremacy Games basically mc is just an average somewhat strong dude who died and went back in time to before earth was discovered by aliens so he got to redo his life and is currently in the series the strongest human alive and contesting against races that humans would never even think of fighting against and there is kinda a romance but it doesn't start till like 700 chapters in and mc is prioritizing getting stronger
This Omega is Immune to All Abilities Thrive in Catastrophe - It's set in a zombie apocalypse, but the technology mentioned is quite futuristic The Film Emperor’s Daily Live Cooking Broadcast Surprise! The Supposed Talent Show Was Actually–?! Number One Lazy Merchant of the Beast World Interstellar Rare Species